Lymphocyte Transformation in Multiple Sclerosis
نویسندگان
چکیده
منابع مشابه
Lymphocyte subpopulations in patients with multiple sclerosis.
Using monoclonal antibodies, peripheral blood helper/inducer (OKT4) and cytotoxic/suppressor (OKT8) lymphocytes were measured in 14 normal controls, 36 patients with multiple sclerosis at different stages of the disease and 15 patients with isolated optic neuritis. Thirty-four of these individuals were studied on two or more occasions at intervals up to 340 days. Patients with multiple sclerosi...
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Following lymphocyte depletion, homeostatic mechanisms drive the reconstitution of lymphocytes. We prospectively studied this process in 16 patients for 1 year after a single pulse of treatment with Campath-1H, a humanised anti-CD52 monoclonal antibody. We observed two phases of lymphocyte reconstitution. In the first 6 months after treatment the precursor frequency and proliferation index of t...
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Altered morphological response of lymphocytes in the presence of antigenic stimulus in vitro may constitute an inter.sting clue to the knowledge of immunological mechanisms in multiple sclerosis (MS). It may serve as a diagnostic test and help in the evaluation of the clinical effect of anti-inflammatory and immunosuppressive agents (Hughes, Caspary, and Field, 1968; Saunders, Knowles, and Fiel...
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Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS). This highlydisabling disorder is characterized by a variable clinical course. MS is a heterogeneous disease with acomplex pathology and significant social and economic impact. MS is associated with dysfunction ofparts of the nervous system which results in a range of signs and symptoms, ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1970
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5701.91